054 - Reaching deep into the brain

About this Video

• Video Title: 054 - Reaching deep into the brain
• Channel: Jarred Younger, PhD
• Speakers: Jarred Younger, PhD
• Duration: 00:05:53

Introduction

This video provides an update on the development and application of transcranial focused ultrasound (tFUS) technology for treating chronic diseases like fibromyalgia, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), long COVID, and Gulf War illness. Dr. Younger explains how this technology allows for precise targeting of deep brain regions to modulate neuronal activity and potentially alleviate symptoms.

Key Takeaways

• Precise Deep Brain Targeting: tFUS uses high-frequency sound waves to non-invasively target specific brain regions, unlike previous methods that were either too superficial or invasive.
• Mechanism of Action: tFUS can alter brain function by changing neuronal firing, ablating regions, opening the blood-brain barrier, and switching microglia from an inflammatory to an anti-inflammatory state.
• Technological Advancement: Several companies are developing tFUS devices, seeking FDA approval for medical use. The technology is rapidly advancing, with potential for at-home devices.
• Dr. Younger's Research Plan: Dr. Younger plans to test the effectiveness of tFUS on brain regions identified through neuroimaging in patients with ME/CFS and similar conditions, with the goal of conducting clinical trials.
• Potential for Treatment: tFUS offers a potential new treatment for chronic conditions characterized by brain inflammation and related symptoms like post-exertional malaise, chronic fatigue, cognitive impairment, and chronic widespread pain.