About this Video

• Video Title: 100 Supplements Ranked Worst to Best (Ultimate Supplement Tier List 2025)
• Channel: Siim Land
• Speakers: Siim Land (assumed based on channel name)
• Duration: 00:56:46

Introduction

This video presents a comprehensive ranking of 100 popular supplements, categorized from "junk" to "god tier" based on scientific evidence. The speaker analyzes each supplement's efficacy, citing human clinical trials whenever possible, and provides timestamps for easy navigation.

Key Takeaways

• The video provides a tiered ranking system for 100 supplements, evaluating their effectiveness based on scientific evidence.
• Supplements are categorized into tiers ranging from "junk" to "god tier," with detailed explanations for each ranking.
• The speaker prioritizes human clinical trial data as the highest quality of evidence when assessing supplement efficacy.
• The speaker's personal experience and preferences are also considered, while acknowledging that personal responses may vary.
• The video emphasizes that not all supplements are suitable for everyone; individual health conditions and needs should be considered when selecting supplements.

The transcript lists the following 100 supplements, although the order is not necessarily the order of ranking presented in the video:

1. Calcium Alpha-Ketoglutarate (Ca-AKG)
2. NMN (Nicotinamide mononucleotide)
3. NR (Nicotinamide riboside)
4. NAM (Nicotinamide)
5. Niacin
6. Quercetin
7. Fisetin
8. Epigallocatechin gallate (EGCG)
9. Epigenin
10. Glycine
11. Trimethylglycine (TMG)
12. Glucosamine sulfate
13. Taurine
14. MSM (Methylsulfonylmethane)
15. Chondroitin sulfate
16. Turmeric (Curcumin)
17. Ashwagandha
18. Citrulline
19. Thiamine (Vitamin B1)
20. Chromium
21. Melatonin
22. Theanine
23. Rhodiola rosea
24. Vitamin C
25. Methylated B vitamins
26. Ginger
27. Sulforaphane
28. Resveratrol
29. Pterostilbene
30. Rapamycin
31. Metformin
32. Spermidine
33. Wheat germ
34. Multivitamin
35. Vitamin E tocotrienols
36. Methylene blue
37. Nicotine
38. Lutein
39. Zeaxanthin
40. Lycopene
41. Beta-carotene
42. Molecular hydrogen
43. Cocoa flavanols
44. Spirulina
45. Berberine
46. Creatine
47. Vitamin E tocopherol
48. Aspirin
49. Vitamin D3
50. Magnesium (various forms: glycinate, threonate, malate, orotate, oxide, citrate)
51. Collagen peptides
52. Glutathione
53. Vitamin K2
54. Vitamin K1
55. Carnosine
56. Whey protein
57. Essential amino acids
58. BCAAs (Branched-chain amino acids)
59. Glutamine
60. Psyllium husk
61. Caffeine
62. Aged garlic extract
63. Ergothioneine
64. Red yeast rice extract
65. Tongkat ali
66. DHEA (Dehydroepiandrosterone)
67. Lithium orotate
68. Omega-3 fatty acids (various sources: krill oil, fish oil, algae oil)
69. SIRT6 (supplements)
70. NAC (N-acetylcysteine)
71. CoQ10 (Coenzyme Q10)
72. PQQ (Pyrroloquinoline quinone)
73. Hyaluronic acid
74. Boron
75. Inositol
76. Electrolytes
77. Zinc
78. Ginseng
79. Shilajit
80. Ginkgo biloba
81. Tribulus terrestris
82. Turkesterone
83. MCT oil (Medium-chain triglycerides)
84. Iron
85. GHK-Cu (Glycyl-L-histidyl-L-lysine copper complex)
86. Iodine
87. Calcium
88. Beta-alanine
89. HMB (Beta-hydroxy-beta-methylbutyrate)
90. Saffron
91. Probiotics (various strains)
92. Prebiotics (various types)
93. Nattokinase
94. Digestive enzymes
95. Astaxanthin

Please note that the transcript mentions "seed" as a specific probiotic brand, and that coffee is discussed in relation to caffeine. These are not included in the numbered list above as distinct supplements.