This video discusses an incident where a professional golfer experienced adverse effects after taking a large dose of creatine. The speaker explores potential reasons for these symptoms, including dehydration, neurotransmitter imbalances, and blood sugar fluctuations, while also examining the scientific literature on creatine's safety and efficacy, particularly regarding high doses, cognitive function, and physical performance. The video also touches upon real-world side effects like GI distress and water retention, and offers advice on optimal timing and methods for creatine supplementation.