Dr. Amir Karam explains the underlying causes of premature aging, focusing on how skin ages faster than a person's chronological age. He identifies key factors contributing to accelerated aging, such as sun exposure, poor skincare, smoking, alcohol, stress, poor sleep, diet, and genetics interacting with lifestyle. The video also offers practical solutions, including medical-grade skincare, daily sunscreen use, lifestyle adjustments, in-office treatments, and surgical options for significant sagging, emphasizing prevention and consistent care.