Boost NAD+ with POWERFUL 5-Amino-1MQ & Apigenin Combo?

About this video

• Video Title: Boost NAD+ with POWERFUL 5-Amino-1MQ & Apigenin Combo?
• Channel: The Enhanced Man
• Speakers: [Speaker's name not available in transcript]
• Duration: 00:09:44

Overview

This video discusses strategies to boost NAD+ levels, focusing on the limitations of common NAD+ precursors like NR and NMN when the enzyme CD38 is elevated. The speaker introduces 5-Amino-1MQ and Apigenin as agents for NAD salvage and explores their benefits, personal experiences, and optimal usage.

Key takeaways

• NAD+ Boosting Limitations: Common NAD+ boosting supplements like NR and NMN can be ineffective if the enzyme CD38 is high, as it degrades NAD+, or if NMMC is high, which diverts nicotinamide. This is likened to pouring supplements into a leaky bucket.
• 5-Amino-1MQ as an NMMT Inhibitor: This compound inhibits NMMT (nicotinamide N-methyltransferase), allowing more nicotinamide (NAM) to enter the NAD salvage pathway, thereby improving NAD+ levels and reducing wasteful processes.
• Benefits of 5-Amino-1MQ: The speaker notes potential benefits such as reduced arterial stiffening, improved nitric oxide balance, enhanced satellite cell function in muscles, reduction of visceral fat, and improved insulin sensitivity and glucose tolerance.
• Apigenin as a CD38 Reducer: Apigenin is discussed as a supplement that can help lower CD38 levels. It also offers neurocalming effects by supporting GABAergic signaling, potentially reducing excitotoxicity.
• Importance of NAD+ Salvage Pathways: The video emphasizes that focusing solely on NAD+ precursors without addressing the salvage pathways (like inhibiting NMMT or CD38) can lead to inefficient NAD+ boosting and potentially negative outcomes.