Cascade of Labs Leading to the Death Cycle - Lactic Acidosis | Modern Article Review

About this video

• Video Title: Cascade of Labs Leading to the Death Cycle - Lactic Acidosis | Modern Article Review
• Channel: Dr. Darren Schmidt, DC
• Speakers: Dr. Darren Schmidt
• Duration: 00:33:04

Overview

This video discusses the concept of a "cascade of labs" that appear chronologically as a person's health deteriorates over decades, leading to chronic disease and ultimately, lactic acidosis. Dr. Schmidt reviews a recent study on lactic acidosis and explains its underlying mechanisms, causes, and implications for overall health and mortality. He emphasizes the role of diet and lifestyle in preventing and managing this condition.

Key takeaways

• Chronic Disease Progression: A series of abnormal lab results, starting with high insulin in adolescence and progressing through issues like high cholesterol, high blood pressure, fatty liver, and kidney dysfunction, can precede overt diseases like heart disease or cancer by decades.
• Lactic Acidosis as an Underlying Mechanism: Lactic acidosis is presented as the fundamental issue underlying many chronic diseases. It occurs when there's an imbalance between lactic acid production and its clearance by the liver and kidneys.
• Diet and Lifestyle Impact: Poor diet (high in refined carbs, sugar, processed foods, and seed oils) and a sedentary lifestyle contribute to metabolic dysfunction and impaired mitochondrial function, exacerbating lactic acidosis. Conversely, a meat-based, low-carb diet, fasting, and exercise can improve mitochondrial health.
• Two Types of Lactic Acidosis: Type A is related to poor circulation and oxygen delivery (hypoperfusion, hypoxia), while Type B is associated with other factors like liver dysfunction, mitochondrial dysfunction, certain medications (e.g., Metformin), cancer, and intoxication.
• Importance of Mitochondrial Health: Healthy mitochondria are crucial for efficient energy production using fat and ketones. Dysfunction leads to reliance on less efficient pathways like the lactic acid cycle, which produces negative ATP, contributing to a "death cycle" of cellular starvation and breakdown.