About this Video

• Video Title: David Sinclair NEW August 2025 Supplement Routine | HUGE Changes!!
• Channel: Wellness Messiah with Rimon
• Speakers: Rimon (primarily), David Sinclair (via audio clips)
• Duration: 00:23:42

Introduction

This video analyzes and summarizes the updated August 2025 supplement and medication routine of Dr. David Sinclair, a prominent researcher in the field of longevity. The video highlights significant changes in Sinclair's regimen, comparing it to previous years, and provides dosage information where available.

Key Takeaways

• Nattokinase: Dr. Sinclair takes 6,000-12,000 units daily to support cardiovascular health.
• Creatine: Sinclair does not currently take creatine.
• Berberine: Sinclair switched from Metformin to Berberine, taking 500mg-1000mg twice daily before meals.
• NMN: Sinclair continues to take 1g of NMN daily but expresses concerns about the quality and purity of many NMN supplements on the market. He recommends caution and suggests safer alternatives like Nicotinamide Riboside (NR).
• Fisetin: Sinclair takes 500mg daily. He no longer takes quercetin.
• Alpha-Lipoic Acid: Sinclair has taken this supplement for 15 years, with a presumed dose of 300-600mg daily.
• Resveratrol: Sinclair continues taking 1g daily, currently mixed with coconut yogurt.
• TMG (Trimethylglycine): Sinclair has stopped taking TMG, citing a lack of evidence supporting its use with NMN or NR.
• Spermidine: Sinclair takes 1-2mg daily; the video also notes that significant amounts are found naturally in foods like mushrooms, peas, and broccoli.
• Sleep Formula: Sinclair uses a proprietary sleep aid containing low-dose melatonin, 5-HTP, and theanine.
• Taurine: Sinclair takes 2g daily.
• Metformin: Sinclair takes 1g, but less frequently than before, having largely replaced it with Berberine.
• Baby Aspirin: Sinclair takes 81mg daily.
• Cholesterol-lowering medication: Sinclair takes this for genetic reasons, not anti-aging purposes.
• Rapamycin: Sinclair takes Rapamycin infrequently, only 4 times per year, expressing reduced enthusiasm due to the results of recent studies.

Based on the transcript, Dr. Sinclair avoids:

• Excessive doses of quercetin: He previously took it with fisetin but has since stopped taking quercetin. The speaker explains that excessive supplementation can have negative consequences, particularly for those under 60.
• Excessive amounts of metformin: While he still uses it, he has significantly reduced his intake, largely replacing it with Berberine.
• TMG (trimethylglycine): He has stopped taking this supplement due to a lack of evidence supporting its use with NAD boosters.
• Regular use of Rapamycin: While he still occasionally takes it, he's significantly reduced his usage and now takes it only a few times per year.

The video also cautions against using certain NMN brands due to the presence of endotoxins and discrepancies between label claims and actual contents. While not something Sinclair avoids, it's a warning regarding product selection.