Do Beta Blockers Really Help You Live Longer?

About this video

• Video Title: Do Beta Blockers Really Help You Live Longer?
• Channel: The Enhanced Man
• Speakers: [Speaker's name not explicitly mentioned in the transcript]
• Duration: 00:09:53

Overview

This video explores the potential longevity benefits of beta blockers, specifically comparing Nebivolol and Propranolol. It discusses their mechanisms of action, dosing protocols, and individual responses, using analogies and personal experiences to illustrate their effects on heart rate, blood pressure, and overall healthspan.

Key takeaways

• Beta Blockers and Longevity: While studies in mice show modest or negligible lifespan improvements with beta blockers, the speaker believes there's more nuance for humans, focusing on mechanisms and dosing.
• Nebivolol: A third-generation beta-1 blocker that increases nitric oxide production, leading to vasodilation and potential anti-inflammatory effects. Some studies show a modest lifespan increase in males, but results vary.
• Propranolol: A non-selective beta-1 and beta-2 blocker that is lipophilic and can cross the blood-brain barrier. It has potential anxiety-reducing benefits but can negatively impact exercise performance by limiting vasodilation and heart rate.
• Individual Response: The effectiveness and side effects of beta blockers are highly person-specific, influenced by genetics, lifestyle, and other medications.
• Personal Experimentation: The speaker is experimenting with different beta blockers and dosages, monitoring metrics like V2 max, heart rate variability, and blood pressure to determine optimal use for longevity.
• Metabolic Health: Maintaining good metabolic health, including managing blood pressure, cholesterol, and blood sugar, is crucial for healthspan, regardless of beta blocker use.