Drug-Drug Interaction Mnemonics (Memorable Psychopharmacology Lecture 15)

About this Video

• Video Title: Drug-Drug Interaction Mnemonics (Memorable Psychopharmacology Lecture 15)
• Channel: Memorable Psychiatry and Neurology
• Speakers: The video only identifies one speaker. The speaker's name is not provided in the transcript.
• Duration: 21:21

Introduction

This video lecture focuses on simplifying the understanding of psychotropic drug-drug interactions. The speaker aims to provide memorable mnemonics to help viewers recall clinically significant interactions, rather than memorizing every possible interaction.

Key Takeaways

• Drug-drug interactions: One drug affecting another, often negatively or unintentionally. This happens either through additive effects (too strong combined effect) or altered drug metabolism.
• Drug metabolism: Most psychotropic drugs are metabolized in the liver by various enzyme systems (e.g., 2D6, 3A4). Inducers speed up metabolism, decreasing drug levels; inhibitors slow metabolism, increasing drug levels.
• Clinically significant interactions: Focus on strong interactions, those with bad outcomes if ignored, or those with non-obvious effects. The speaker highlights strong inducers (carbamazepine, phenobarbital) and inhibitors (bupropion, fluoxetine, paroxetine).
• Mnemonics: The speaker introduces "I CAN HAVE FUN HEARTILY OUTSMARTING WARRING DRUGS" to remember clinically significant interactions, explaining each letter's corresponding medication class or condition.
• Non-prescription interactions: The lecture emphasizes the importance of considering non-prescription substances like nicotine, alcohol, grapefruit juice, and St. John's Wort, which can significantly influence drug metabolism. Also, the speaker highlights that three benzodiazepines (oxazepam, temazepam, lorazepam) are relatively safe for patients with liver dysfunction because they're metabolized differently.