This video explains the process of granulation in pharmaceutical manufacturing, highlighting its importance in creating stable, effective, and safely delivered medications. It covers what granules are, why they are essential, various methods of production (wet and dry granulation), specialized types of granules (e.g., effervescent, coated), and the rigorous quality control measures involved.
The two primary reasons granulation is performed are:
Slugging, also known as pre-compression, is a dry granulation technique where the powder mixture is first compressed into very large, coarse tablets. These large tablets, called "slugs," are not intended for direct consumption but are then broken down and milled into smaller granules of the desired size. This process effectively compacts the powders under high pressure, allowing them to bind together mechanically.
Bu video, farmasötik üretimde granülasyon sürecini anlatıyor ve stabil, etkili ve güvenli bir şekilde sunulan ilaçların oluşturulmasındaki önemini vurguluyor. Granüllerin ne olduğunu, neden gerekli olduklarını, çeşitli üretim yöntemlerini (yaş ve kuru granülasyon), özel granül türlerini (örn. efervesan, kaplanmış) ve uygulanan titiz kalite kontrol önlemlerini ele alıyor.
Dry granulation differs from wet granulation primarily by the absence of a liquid binder.
Wet granulation involves adding a liquid (like water or an alcohol-based solution with a binder) to the powder mixture to create a cohesive mass, which is then processed and dried.
Dry granulation avoids liquids altogether. It relies on mechanical force to bind the powders. This method is preferred in specific situations:
