The fastest magnesium turnover is in the blood and extracellular fluid, which can change within hours or days. The slowest turnover is in the deep bone matrix, estimated to have a half-life of around 1,000 days, meaning it takes years to fully replenish.
Overusing Vitamin D or calcium without sufficient magnesium can worsen a deficiency, as both nutrients increase magnesium requirements and can deplete it faster than it can be replenished.
Splitting your magnesium dose into two to three smaller servings throughout the day can help avoid spikes in blood levels that get wasted in urine, thus aiding in better uptake.
This video explains why magnesium deficiency is common and how long it truly takes to correct it at a cellular level. It details where magnesium is stored in the body, the varying turnover rates of different tissues, and strategies to improve magnesium uptake while avoiding depleting factors.