Is Nicotinic Acid Bad For Longevity?

About this video

• Video Title: Is Nicotinic Acid Bad For Longevity?
• Channel: Conquer Aging Or Die Trying! Mike Lustgarten, PhD;
• Speakers: Mike Lustgarten
• Duration: 00:12:48

Overview

This video explores the relationship between specific triglycerides, longevity, and the potential impact of nicotinic acid (niacin) intake. Mike Lustgarten analyzes research on longevity interventions in mice, human data on all-cause mortality, and his personal biomarker data to investigate if higher niacin intake is associated with increased levels of certain triglycerides linked to reduced longevity.

Key takeaways

• Longevity Interventions and Triglycerides: Several longevity-extending interventions in mice, including rapamycin and calorie restriction, have been associated with downregulated levels of specific triglycerides, such as TG483 and TG-53.
• Human Mortality Data: Human studies indicate that higher levels of certain triglycerides (e.g., TG483 and TG-53) are associated with increased all-cause mortality risk and a decreased chance of reaching advanced age.
• Niacin Intake and Triglycerides: Personal data analysis suggests a positive correlation between niacin intake and higher levels of TG483 and TG-53. This implies that nicotinic acid supplementation might negatively impact these longevity-associated triglycerides.
• Total Triglycerides as a Proxy: Total triglyceride levels measured via venipuncture do not appear to be a reliable proxy for the specific triglycerides TG483 and TG-53.
• Nicotinic Acid vs. Nicotinamide: The video raises questions about whether nicotinic acid and nicotinamide have similar effects on these specific triglycerides and NAD levels, with plans to investigate nicotinamide in future tests.