The speaker uses a canvas size of 4000 x 6000 pixels and a DPI of 300 in Clip Studio Paint. They note that 72 DPI is sufficient if printing isn't necessary.
The speaker advises those struggling with VTuber model design to post their designs online and ask for feedback, watch videos discussing YouTuber designs and important aspects like color, themes, and aesthetics, and to consider the silhouette of their design.
This video documents the creator's process of designing and creating a new VTuber model. The video covers the design process, artistic creation using Clip Studio Paint (with some Procreate), and provides tips for creating VTuber models, particularly focusing on more advanced rigging techniques in subsequent videos.