TΔS represents the contribution of entropy to the overall free energy change of a reaction, adjusted by the temperature at which the reaction occurs. In simpler terms, it quantifies the energy associated with the disorder or randomness of a system. The 'T' stands for temperature (measured in Kelvin), and 'ΔS' represents the change in entropy.
This video explains the concept of free energy in metabolism, emphasizing that it's the only form of energy cells can use to perform work. It details how negative free energy changes (ΔG) indicate spontaneous and favorable reactions that release energy, while positive ΔG signifies non-spontaneous, unfavorable reactions that require energy input. The video also introduces the Gibbs free energy equation (ΔG = ΔH - TΔS) and its components: enthalpy (ΔH) and entropy (ΔS), explaining how temperature influences these factors.