Olive Oil Fasting Doubles Autophagy and Stops Insulin Resistance (just one day)

About this video

• Video Title: Olive Oil Fasting Doubles Autophagy and Stops Insulin Resistance (just one day)
• Channel: Thomas DeLauer
• Speakers: Thomas DeLauer
• Duration: 11:48

Overview

This video explains how to leverage olive oil, specifically its compound oleocanthal, to mimic the benefits of fasting, such as increased autophagy and reduced insulin resistance, without the need for prolonged caloric restriction. It details the biochemical mechanisms involving AMPK and mTOR, and how to incorporate olive oil, MCT oil, and exogenous ketones into a protocol to enhance cellular cleanup, repair, and longevity.

Key takeaways

• Olive Oil as a Fasting Mimic: High-quality extra virgin olive oil, due to its oleocanthal compound, can trick the body into activating cellular cleanup processes similar to fasting, by directly activating AMPK and suppressing mTOR.
• Autophagy Activation: Oleocanthal initiates autophagy, a cellular recycling process that removes damaged components like misfolded proteins, dysfunctional mitochondria, and senescent (zombie) cells, thereby combating inflammation and age-related diseases.
• Metabolic Switching: The protocol helps build metabolic flexibility by training the body to utilize ketones, enhancing energy stability and supporting weight management.
• Longevity Gene Activation: Ketones, particularly beta-hydroxybutyrate (BHB), act as HDAC inhibitors, unlocking longevity and repair genes like FOXO3, essentially upgrading cellular software.
• Practical Protocol: A simple protocol involves consuming 1-2 teaspoons of high-quality extra virgin olive oil with MCT oil or exogenous ketones every few hours for a day, replacing normal meals to gain fasting-like benefits without severe calorie restriction.