Sam Altman's opening keynote at OpenAI DevDay 2025 highlights the significant growth and advancements in AI development and adoption over the past two years. He introduces new tools and features designed to empower developers, including the Apps SDK for building within ChatGPT, AgentKit for creating AI agents, updates to Codex for software development, and model advancements like GPT-5 Pro and Sora 2. The overarching theme is making AI more accessible and powerful for builders to create innovative applications and solutions.