About this Video

• Video Title: Scientists Are Discovering a New Driver of Aging
• Channel: Siim Land
• Speakers: Siim Land
• Duration: 00:08:47

Introduction

This video explores circadian clock dysfunction as a potential 13th hallmark of aging. The speaker, Siim Land, discusses how disruptions to the body's natural daily rhythms affect hormone production, leading to various health problems and accelerated aging. He proposes strategies to improve circadian rhythm alignment to mitigate these effects.

Key Takeaways

• Circadian rhythm dysfunction: The body's internal clock (circadian rhythm) regulates various bodily functions. Its disruption, characterized by reduced fluctuation in hormones like cortisol and melatonin, is linked to accelerated aging. This is described as "chronic jet lag syndrome."
• Consequences of disruption: Circadian rhythm disruption increases the risk of neurodegeneration, cancer, diabetes, obesity, hypertension, and heart disease. It also leads to poorer sleep, inflammation, metabolic health, and lower energy levels.
• Improving circadian rhythm: Strategies to improve circadian rhythms include: morning bright light exposure (at least 10-15 minutes), possibly caffeine supplementation for older individuals, morning exercise, blocking blue light at night, maintaining a consistent sleep schedule, and regular mealtimes.
• Role of NAD: NAD (nicotinamide adenine dinucleotide) is a key metabolite involved in energy metabolism and maintaining circadian clock robustness. Low NAD levels are associated with both aging and circadian disruption, creating a vicious cycle. Increasing NAD through calorie restriction, time-restricted eating, exercise, and polyphenols may help.
• Overall health: While perfectly aligning circadian rhythms won't grant immortality, it can significantly improve health and slow down the aging process.