This video discusses various supplements related to sleep, focusing primarily on melatonin. It explains melatonin's function as a hormone of darkness rather than a direct sleep inducer, its potential effectiveness for those without conditioned arousal, and issues with supplement quality control. The video also touches on other supplements like magnesium, glycine, and L-theanine, distinguishing between sleep-inducing and calming effects, and advises against taking certain B vitamins at night.