About this video

• Video Title: TB4 vs TB-500: One Is Studied. One Is Marketed.
• Channel: Peptide Buddy
• Speakers: [No speaker names available in the transcript]
• Duration: 13:42

Overview

This video aims to clarify the distinction between TB4 and TB-500, focusing on the scientific research and clinical applications of TB4. It explains that TB-500 is a fragment of TB4 and highlights the marketing discrepancies surrounding these compounds, emphasizing the importance of understanding the research behind them.

Key takeaways

• Distinction between TB4 and TB-500: TB-500 is an isolated fragment of TB4 (amino acids 17-23), while TB4 is the full 43-amino acid peptide. There is limited data supporting the use of TB-500, and its marketed claims are not well-supported by research.
• TB4 Research Focus: The video centers on TB4 (Thymosin Beta 4), a peptide known for its angiogenic and anti-apoptotic properties, playing roles in tissue recovery, hair growth, and inflammation modulation.
• Clinical Trial Overview: The video discusses Phase 1 trials for TB4, noting adverse effects like headaches and dizziness, and a half-life between 1-2 hours. It also touches upon Phase 2 trials for venous ulcers and dry eye, with mixed results and limitations in statistical significance.
• Ophthalmological Research: Significant research on TB4 has focused on eye conditions like dry eye and neurotrophic keratitis, with some promising but preliminary results, particularly for a product designated orphan status by the FDA.
• Potential Risks: Concerns are raised about TB4's angiogenic and anti-apoptotic properties potentially supporting cancerous growth and spread, warranting caution, especially for individuals at higher risk for tumors.

TB-500 is an isolated fragment of TB4, specifically amino acids 17 through 23, whereas TB4 is the complete 43-amino acid peptide. The video states there is very little data supporting the use of TB-500, and its purported benefits, such as hair growth stimulation, are not well-supported by evidence. The speaker notes that some companies market TB4 as TB-500, creating confusion for consumers.