Robert Muggah's TED Talk discusses the significant risks facing cities globally, particularly emphasizing the increasing fragility of many urban centers and the resulting displacement and refugee crises. He highlights the disproportionate environmental impact of cities and the need for innovative solutions, arguing that cities hold the key to navigating the challenges of the 21st century. He presents data visualizations and case studies to illustrate his points and proposes six key principles for building more resilient cities.