This Huberman Lab podcast features Dr. David Sinclair, a Harvard genetics professor, discussing the biology of aging and practical tools to slow or reverse its effects. The conversation covers various aspects of aging, including the role of the epigenome, nutritional interventions (like fasting and specific food choices), supplementation (such as resveratrol, NMN, and Metformin), and behavioral interventions (like cold exposure). The podcast aims to provide listeners with in-depth knowledge and actionable strategies for improving longevity and health.
Based solely on the provided transcript, here's what is discussed about resveratrol:
Dr. Sinclair mentions resveratrol, a molecule found in red wine, as an activator of sirtuins, a group of longevity genes. He explains that while resveratrol has shown benefits in protecting against high-fat diets in mice, its effects are more significant when administered intermittently (every other day) rather than continuously. This intermittent dosing significantly extended lifespan in mice, more so than continuous administration, even on a normal diet. Dr. Sinclair personally takes 1000 milligrams of resveratrol daily, dissolved in olive oil (because olive oil, particularly oleic acid, also activates sirtuin defenses) along with other supplements to enhance absorption. He notes that high-quality resveratrol should be light gray or white; brown resveratrol indicates spoilage or contamination.
Based on the transcript, Dr. Sinclair mentions that he uses a "pulsing" protocol for several things, implying intermittent application. These include:
The transcript doesn't explicitly list other procedures performed intermittently, though the concept of "pulsing" various interventions is a key theme.
