The End of Insulin Resistance (Stop it in Weeks NOT YEARS)

About this video

• Video Title: The End of Insulin Resistance (Stop it in Weeks NOT YEARS)
• Channel: Thomas DeLauer
• Speakers: Thomas DeLauer
• Duration: 17:02

Overview

This video explains insulin resistance, distinguishing it from diabetes, and discusses its prevalence, even in lean individuals. It details the cellular mechanisms behind insulin resistance, including the role of DAG (diacylglycerol) and inflammation. The video provides a toolkit of actionable steps to combat insulin resistance, such as post-meal walks, strategic carbohydrate use, supplements like carnosine and TMG, incorporating cinnamon, and practicing intermittent fasting.

Key takeaways

• Insulin Resistance vs. Diabetes: Insulin resistance is described as a "long smoldering fire," while type 2 diabetes is when "the house is actually burning down." Both are correctable, but addressing insulin resistance early is easier.
• Prevalence and Misconceptions: A significant percentage of young adults (18-44) have insulin resistance, and many are not obese, highlighting the "thin outside fat inside" phenomenon. Doctors may miss early signs because they only check fasting glucose, not fasting insulin.
• Cellular Mechanisms: Insulin resistance occurs when muscle cells ignore insulin's "key" to let glucose in, causing the pancreas to overproduce insulin. Inflammation and a fat-derived metabolite called diacylglycerol (DAG) jam the signal to the GLUT4 transporter (the "garage door" for glucose).
• Actionable Toolkit:
  • Post-meal walks (10-15 mins): Activates a secondary pathway (AMPK) that opens GLUT4 doors, bypassing insulin.
  • Strategic Carb Use: Consuming fast-digesting carbs during or immediately after exercise allows glucose to be shuttled directly into working muscles for fuel.
  • Protein and Soluble Fiber: Slows the absorption of carbs and fats, preventing the "overflow" that leads to DAG buildup. Examples include psyllium husk, chia seeds, and acacia fiber.
  • Supplements:
    • Carnosine: Acts as a "sacrificial shield" by intercepting sticky sugar molecules and preventing glycation damage.
    • TMG (Trimethylglycine): Supports mitochondrial function and activates AMPK, helping the body burn excess fatty acids for fuel and prevent DAG formation.
    • Cinnamon: Acts as an insulin mimetic, making insulin receptors more sensitive to insulin's signal.
  • Intermittent Fasting: Acts as a "master reset," dramatically lowering insulin, increasing AMPK and autophagy (cellular cleanup of DAGs), and forcing the body to burn stored fat.
• DAG Sludge: This thick, sticky metabolite, caused by overnutrition and excess fatty acids, seeps into the receiver of the GLUT4 transporter, jamming the signal. Exercise, TMG, and fasting help to clear it out.
• Insulin Resistance as a Survival Tool: During fasting, the body temporarily makes muscles insulin resistant to spare glucose for the brain. The issue in modern society is that constant overnutrition tricks the body into this state inappropriately.