The hidden hormone behind insulin resistance nobody talks about

About this Video

• Video Title: The hidden hormone behind insulin resistance nobody talks about
• Channel: Dr. Boz [Annette Bosworth, MD]
• Speakers: Annette Bosworth, MD
• Duration: 00:36:59

Introduction

This video discusses leptin, a hormone often overlooked in discussions of insulin resistance and weight loss. Dr. Bosworth explains the role of leptin in satiety and fat storage regulation, highlighting how imbalances in leptin can lead to obesity and metabolic diseases. The video aims to provide a deeper understanding of leptin resistance and its implications for health.

Key Takeaways

1. Leptin's Dual Role: Leptin signals satiety (fullness) to the brain and regulates fat storage. Both leptin deficiency and excess can lead to obesity.
2. Leptin Resistance: When fat cells overgrow, leptin levels become chronically elevated, and the brain becomes desensitized to its signals, leading to continued weight gain despite efforts to restrict food intake. This resistance also contributes to insulin resistance and cardiovascular disease.
3. Leptin Resistance and Disease: Leptin resistance is linked to insulin resistance, high blood sugar, increased risk of diabetes, and cardiovascular issues like atherosclerosis (hardening of the arteries) due to impaired lipoprotein recycling.
4. Reversing Leptin Resistance: Dr. Bosworth emphasizes that reversing leptin resistance requires a ketogenic state, achieved through dietary changes and/or ketone supplementation. This helps reset leptin signaling and improve metabolic function. She suggests pulsing ketones (taking them at multiple times during the day for a period of time) as a strategy to initiate this process.