This Patchwork Podcast episode features Anaby, an anonymous scientist and PhD dropout, discussing his "honey diet" and its effects on metabolism. The conversation explores the diet's theoretical mechanisms, practical applications, potential pitfalls, and considerations for individual variations in metabolic responses.
The Honey Diet's Core Theory: The diet aims to leverage the hormone FGF21, induced by overeating carbohydrates and fats while being protein-deficient. FGF21 increases energy expenditure and creates an aversion to sweets while increasing protein cravings. This theoretically allows for weight loss or maintenance while consuming high sugar.
Protein Timing is Crucial: Consuming a significant protein meal later in the day (e.g., dinner) is key to preventing the blunting of the FGF21 response. The timing allows for a period of high sugar intake, followed by a protein-induced, transient insulin resistance which may facilitate weight loss.
Individual Variation and Pitfalls: The diet's effectiveness varies significantly between individuals. Factors like gut inflammation, raw starch consumption, and individual genetic predispositions (e.g., ALDH2 mutation, MTHFR mutation, fructose intolerance) can influence results.
Potential Benefits Beyond Weight Loss: Anecdotal evidence suggests potential benefits beyond weight loss, including improved mental clarity and energy levels, and potentially better vacation weight management. However, these need further scientific validation.
Further Research Needed: A large-scale study with quantitative data on caloric intake, weight changes, and individual metabolic markers is needed to validate the honey diet’s mechanisms and refine its protocols.
