This video features a conversation between Noah Ryan and Anabology about Anabology's "honey diet." The discussion covers the diet's evolution, its effectiveness in different climates, the role of the hormone FGF21, the importance of fatty acid composition in the diet, and the potential impact of various supplements on metabolic processes. They also touch upon broader topics such as the relationship between metabolic rate and lifespan, and Anabology's current experiments to improve cognition.
Honey Diet Basics: Anabology's original honey diet involved maximizing sugar intake early in the day and consuming a large protein meal later, based on animal studies showing that high sugar intake didn't lead to weight gain in animals.
Seasonal Variations: The diet's effectiveness seems to vary with the season; it worked well in a cold climate but may be less effective in warmer climates due to natural craving shifts.
FGF21 Hormone: The diet's effects are partly linked to the hormone FGF21, which increases with high sugar intake, leading to sugar aversion and protein cravings while boosting the metabolic rate.
Importance of Fatty Acids: The composition of fatty acids in the diet is crucial. Minimizing polyunsaturated fatty acids (PUFAs), particularly seed oils, seems beneficial, while increasing saturated fats may improve metabolic efficiency.
Metabolic Flexibility and Cycling: Anabology advocates for a flexible approach, cycling dietary components to maintain metabolic flexibility and avoid plateaus. He suggests a baseline diet and experimentation, with a return to the baseline if needed.
Supplement Use: Anabology uses several supplements including taurine, thiamine, L-carnitine, C3G, CoQ10, and PQQ, to enhance nutrient utilization, fat burning, and mitochondrial function.
Intelligence and Cognition: Anabology is experimenting with EEG devices and various interventions to improve his cognitive function, emphasizing the importance of rapid iteration cycles for self-improvement.
