The non-canonical mechanism of fat loss discovered in the study involves the activation of autophagy (specifically lipophagy) within fat cells. Instead of solely relying on the typical lipolysis process, fasting triggers fat cells to increase the production of autophagy proteins. These proteins create autophagy vesicles that are responsible for breaking down stored fat molecules.
During fasting, fat cells export their fat in vesicles. It's proposed that immune cells then invade the fat tissue, take up these fat vesicles, and deal with them potentially by increasing their own autophagy.
In simple terms, during fasting, your fat cells release fat in little packages. Immune cells then come into the fat tissue, grab these packages, and break them down, possibly by using their own cellular cleanup process called autophagy.
This video discusses a recent study on fasting and its impact on fat loss. The speaker explains how fasting activates a non-canonical mechanism in fat cells, involving autophagy (specifically lipophagy), to break down stored fat, in addition to the usual lipolysis. The video also touches on the correlation between animal studies and human responses, and the potential interaction between fat cells and immune cells during fasting.