This Supplement Is the FASTEST Way to Boost NAD (Forget NMN & NAD Drips)

About this video

• Video Title: This Supplement Is the FASTEST Way to Boost NAD (Forget NMN & NAD Drips)
• Channel: FoundMyFitness Clips
• Speakers: [Speaker names not explicitly mentioned in the transcript]
• Duration: 11:07

Overview

This video explains why directly supplementing with NAD is ineffective and discusses the efficacy and safety of NAD precursors, primarily focusing on nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN). It clarifies the role of phosphates in cellular uptake and addresses the limitations and potential risks associated with NAD IV drips and NMN supplements.

Key takeaways

• NAD Supplementation Issues: Direct NAD supplementation is ineffective because NAD molecules with phosphates cannot enter cells.
• Nicotinamide Riboside (NR) Efficacy: NR is considered a premium NAD precursor because it can enter cells and be converted to NAD. The enzymes responsible for this conversion (NMRK1 and NMRK2) are upregulated in conditions of metabolic stress, suggesting NR's effectiveness in such situations.
• Nicotinamide (NA) and Nicotinic Acid: Nicotinamide and nicotinic acid are NAD precursor vitamins that do not contain phosphates and can enter cells. However, nicotinic acid can cause flushing at high doses, while nicotinamide is considered safe, even cancer preventative, and is found in many multivitamins.
• NMN vs. NR: NMN, while a precursor to NR, has a phosphate group that prevents its direct entry into cells. It is often converted back to NR in the digestive system before absorption. The purity and safety of NMN supplements are also a concern, with reports of products not meeting label claims.
• NAD IV Drips: While NAD IV drips bypass some absorption issues, they can cause an innate immune response because NAD cannot enter cells directly. Intravenous NR is an option, but oral NR has more extensive clinical data regarding safety and efficacy.