Week 01: Lecture 01: Fundamentals of Drug Delivery Systems-I

About this video

• Video Title: Week 01: Lecture 01: Fundamentals of Drug Delivery Systems-I
• Channel: NPTEL IIT Bombay
• Speakers: Dr. Satish Dawanabelli
• Duration: 28:04

Overview

This video introduces the fundamental concepts of drug delivery systems, differentiating between conventional and novel approaches. It explains the challenges in drug discovery and development, the need for advanced drug delivery systems to overcome limitations of conventional methods, and defines what constitutes a drug delivery system. The lecture also touches upon various technologies, examples of novel systems, and common terminologies used in the field.

Key takeaways

• Drug Discovery and Development Challenges: The process is lengthy and complex, involving multiple phases from discovery to clinical trials and regulatory approval. Issues like low solubility and poor permeability of certain drug molecules present significant formulation challenges.
• Need for Novel Drug Delivery Systems (NDDS): Conventional formulations often have limitations such as poor efficacy, side effects, lack of selectivity, and fluctuating drug levels. NDDS aim to improve drug efficacy, safety, bioavailability, and patient compliance through controlled, targeted, and sustained release.
• Definition and Aim of NDDS: Drug delivery systems utilize technologies, formulation approaches, and methods to transport therapeutic compounds to target sites safely and in a controlled manner. The main goal is to optimize drug performance in the body.
• Comparison of Conventional vs. Novel Systems: Novel systems offer advantages like controlled release profiles, improved targeting, reduced dosing frequency, enhanced patient compliance, and better stability for sensitive molecules, although they may involve higher cost, complexity, and regulatory hurdles.
• Key Terminologies: Concepts like controlled release, sustained release, zero-order release, and first-order release are crucial for understanding drug delivery mechanisms.