This video features Dr. Andrew Jenkinson, a bariatric surgeon, explaining the complex reasons behind persistent hunger and obesity. He debunks the "eat less, move more" myth, highlighting the crucial roles of genetics, epigenetics, hormonal regulation (specifically leptin resistance), the body's weight "set point," and the impact of modern diets and lifestyle factors. Dr. Jenkinson offers practical advice on how to shift one's set point and achieve sustainable weight loss by focusing on food quality, reducing sugar and processed foods, and incorporating mindful eating and time-restricted eating.